ABO blood group system;
Classification of human blood based on the inherited properties of red blood cells (erythrocytes) as determined by the peresence of absence of the antigen A and antigen B.
Different human blood type are due to he variation in the surface markers on the RBC.
Medically important because the immune system proteins antibodies -recognize and attack the virtually anything.Any molecule that triggers the defensive attack is called antigen which is RBC bear highly specific surface antigen(a glycoprotien).Presence of surface antigen closely associated with blood typing system ABO system.
RED BLOOD CELL ANTIGEN AND BLOOD TYPING
Antigens is found on the surface of cells to help immune system
recognize self cells .
Antibodies - secreted by lymphocytes in response to foreign
cells . ABO system is antigens on erythrocyte cell surfaces .Type A is has the A antigen, antibody B . Type B is has the B antigen antibody A .Type AB is has both the A and B antigens .Type O is has neither the A nor the B antigen.
BLOOD TRANSFUSION
Process of transferring blood component (part of a whole
blood) from one person into another. The blood used in a transfusion is compatible with one’s blood
type. Blood transfusions can be life-saving (massive blood loss, to
replace blood lost during surgery) .Used to treat a severe anemia or
thrombocytopenia caused by blood
disease (hemophilia, sickle-cell
disease).
TRANSFUSION REACTIONS:
AGGLUTINATION AND HEMOLYSIS
Transfusion reaction (hemolytic) is a serious complication that
can occur after a transfusion of blood. Occurs when mismatched blood type infused . The red blood cells that were given in the transfusion are
destroyed by the patient's immune system. Donor’s RBC will be attacked by the recipient’s plasma
antibodies.
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